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Category:Microsoft Office-related software Category:Machine translation Category:Windows-only software Category:Software companies of FranceThe effects of maternal sugar on the glucocorticoid and thyroid hormone responses of the pregnant rat. Maternal exposure to a high-sugar diet during pregnancy can result in alterations in hypothalamic-pituitary-adrenal (HPA) axis activity in the offspring. However, the effects of maternal high-sugar diets on the thyroid axis of the offspring are largely unexplored. This study was designed to examine the effects of maternal sugar on the glucocorticoid and thyroid hormone responses of the offspring. Adult, pregnant female rats were fed a sucrose-rich diet (High Sugar group; HSG) or standard chow (Control group; CTL) from d16 of pregnancy until parturition. At parturition, maternal and neonatal plasma corticosterone and thyrotrophin (TSH) concentrations were measured, and neonatal pituitary, hypothalamic and liver corticotrophin-releasing hormone (CRH) mRNA abundance and mRNA ratios for GR were determined. Adult offspring of mothers fed a sucrose-rich diet exhibited increased maternal and neonatal plasma corticosterone concentrations and reduced maternal and neonatal pituitary CRH mRNA abundance. Rat offspring of mothers fed sucrose-rich diets had reduced hypothalamic CRH and GR mRNA abundance, as well as reduced hypothalamic, pituitary and liver GR mRNA ratios compared to offspring of chow-fed mothers. These data show that maternal sugar-rich diets are associated with HPA axis and thyroid hormone responses in offspring. These alterations in hypothalamic-pituitary-thyroid (HPT) axis function of the offspring may provide a mechanism for the alterations in the fetal programming of metabolic disease and neuropsychiatric disorders that result from maternal high-sugar diets.The setting sun does not help the weather in the Mojave Desert. It's hot, dusty and in general a lot like the Sahara. But about the size of Pennsylvania, this section of the Mojave is home to the Airstream trailer that is set to go on a 1,000-mile trip around the country that has become a social media sensation. The living trailer, which is on loan from an Arizona couple, is pulling behind them on their 1994 Winnebago as they motor along the eastern edge of the Mojave. The couple, who
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